Endocrine Abstracts

Paragangliomas are rare neuroendocrine tumours that originate from neural crest cells and can arise from any autonomic ganglion of the body. This is a challenging entity given the limited therapeutic options. Here, we present a rare case of metastatic Paraganglioma in a patient with a germline pathogenic succinate dehydrogenase subunit B (SDHB) mutation. A 54 year old lady was initially diagnosed with functioning bladder paraganglioma with raised metanephrine and norm...

57 year old female physiotherapist, diagnosed with osteoporosis following a fibula fracture from a low impact stretch and a wedge vertebral fracture at age 51 with a metatarsal fracture age 54. With associated history of easy bruising, increase abdominal girth although her weight remained stable at 48.5 kg with BMI 19.9 and proximal myopathy. Blood pressure was constantly normal. Investigations: Early morning random Cortisol 564 and ACTH 6.6 (2–11), cort...

Buffalo is a major dairy animal in many countries of the world, including Pakistan. However, the productive and reproductive performance of this species is affected by many physiological problems such as anestrous. Therefore, this study was conducted to compare serum total cholesterol, thyroid hormone concentrations and haematological variables in cyclic and acyclic Nili-Ravi buffaloes. For this purpose, 60 adult Nili-Ravi buffaloes were divided into two equal groups i.e. cycl...

Background: Syndrome of Inappropriate Anti-diuretic Hormone (SIADH) secretion is the most common cause of hyponatremia in cancer patients. About 14% of hyponatremia in medical inpatients is due to underlying tumor-related conditions. We performed an audit to evaluate prevalence of lung malignancy in patients newly diagnosed with SIADH and to assess proportion of patients having radiological evidence of lung cancer through chest x ray and/or CT chest imaging six months after es...

Presentation: A 32-year-old woman was brought to the Emergency Department following an out-of-hospital cardiac arrest. CPR was started by a neighbour and on arrival, she was found to be in ventricular fibrillation (VF). She received 4 DC-shocks and reverted to atrial fibrillation with fast ventricular rate and staged a full cognitive and haemodynamic recovery. She had a 10-year history of Graves’ thyrotoxicosis for which she was on Carbimazole but remained uncontrolled du...

Introduction: Hyponatraemia is one of the most common electrolyte abnormalities seen in clinical practice [1] and can be caused by a myriad of aetiologies.Aim: To report two cases of severe hyponatraemia caused by different aetiologies.Case report: A 56-year-old male patient was admitted with 2 episodes of tonic-clonic seizures at his care home. The patient had a background of small cell lung cancer and brain metastases in late 202...

Background: Congenital hyperinsulinism (CHI) is a heterogeneous genetically determined condition that is characterised by unregulated secretion of insulin from pancreatic β-cells. The most common and severe cases are caused by mutations in the ABCC8 gene encoding the SUR1 subunit of the KATP channel subunit. Autosomal recessive mutations in HADH gene are a rare cause of CHI. The advances in CRISPR/Cas9 gene editing technology has enabled the i...

A 74 years old man prsented with gradually worsening confusion with associated jerky movements with background of well controlled type 2 Diabetes, CKD-3, IHD and previous duodenal ulcer. His was on Finasteride, Omeprazole, Mirtazapine, Tamsulocin, Metformin, Atorvastatin, Humulin I insulin. He was taking omeprazole for Duodenal ulcer since 1993.On examination he had jerky movements of the arms suggestive of muscles spasms. Res...

Teddy is a highly proliferative goat breed, as females of this breed are famous for high twinning rates. Feed supplementation of olive oil has been shown to improve semen quality of goat bucks. In this study, the effects of feed supplementation with olive oil on serum testosterone, triiodothyronine (T3), thyroxine (T4) and some biochemical metabolites in Teddy goat bucks were investigated. For this purpose, 9 adult male goats, with clinically normal reproduc...

Moyamoya disease is a progressive chronic neurological disease due to multiple narrowing of the carotid arteries. It can be seen in association with atherosclerosis, vasculitis, haematological conditions, connective tissue disease, neurocutaneous syndromes and certain autoimmune diseases. Very few cases have been reported in association with Graves disease and the majority being in the East Asian population. We present a rare case of this association in a young C...